Glucose uptake capacity of leukaemia cells in vitro correlates with response to induction therapy in acute myeloid leukaemia (2024)

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Data availability Code availability References Acknowledgements Funding Author information Authors and Affiliations Contributions Corresponding author Ethics declarations Competing interests Ethics approval and consent to participate Additional information Supplementary information Supplementary File Rights and permissions About this article Cite this article

TO THE EDITOR:

Metabolic re-programming is a hallmark of acute myeloid leukemia (AML) [1]. AML cells co-opt bone marrow niche to utilize fatty acid or amino acids to fuel oxidative phosphorylation (OXPHOS), possibly contributing to resistance [2,3,4,5]. We previously reported leukaemia cells compete over bone marrow micro-environment cells on glucose uptake in a MLL-AF9-driven AML mouse model [6]. Whether glucose uptake by leukaemia cells correlates with response to induction chemotherapy is unknown.

Data availability

Raw bulk RNA-sequencing data have been submitted to the Genome Sequence Archive (Genomics, Proteomics & Bioinformatics 2021) in National Genomics Data Center (Nucleic Acids Res 2022), China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Science (GSA-Human: HRA008200) that are publicly accessible at http://ngdc.cncb.ac.cn/gsa-human.

Code availability

Code used for bioinformatic analysis are available on request from corresponding author. Other data are available in the main text or the supplemental materials.

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Acknowledgements

Dr. Xiaoxia Hu (Collaborative Innovation Center of Hematology, Shanghai Jiao Tong University School of Medicine, Shanghai, China), Dr. Min Zhao (Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, China) and Dr. Jie Tian (Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China) kindly reviewed the typescript. We thank Dr. Xi Xu (Department of Haematology, Nanfang Hospital, Southern Medical University, Guangzhou, China), Dr. Shaowei Qiu (State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China) for advice in the PDX models. RPG acknowledges support from the UK National Institute of Health Research (NIHR) Biomedical Research Centre.

Funding

Supported, in part, by the Talent Young Program of Guangdong Province (2021B1515020017), National Natural Science Foundation of China (Grant No. 81970143 and No. 82270167), Municipal School Joint Program from Guangzhou Science and Technological Project (202201020012) to HZ.

Author information

Author notes

  1. These authors contributed equally: Suqi Deng, Juan Du.

Authors and Affiliations

  1. Department of Hematology, the First Affiliated Hospital of Jinan University, Guangzhou, China

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  2. Centre for Haematology, Department of Immunology and Inflammation, Imperial College of Science, Technology and Medicine, London, UK

    Robert Peter Gale

  3. Department of Nuclear Medicine and PET/CT-MRI Center, the First Affiliated Hospital of Jinan University, Guangzhou, China

    Lu Wang&Junjie Wei

  4. Department of Hematology, Guangzhou First People’s Hospital, Guangzhou, China

    Wei Zhou

  5. Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China

    Bo Liu,Zhiyang Chen&Zhenyu Ju

  6. Department of Hematology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

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Authors

  1. Suqi Deng

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Contributions

SQD, data curation, experiment conduction, statistical and transcriptomic analysis, visualization, preparing the typescript; JD, data curation, result interpretation, investigation, preparing and editing the typescript; RPG, data interpretation, reviewing and editing the typescript; LW, JJW and SQX, technical support; KXH, DQP, SQX and WHX, experimental assistance; XZ, YX and WZ, clinical data; BL, ZYC and ZYJ, patient-derived xenografts model construction; HZ, project design, investigation, data interpretation, reviewing and editing the typescript. All authors take responsibility for the content of the typescript and agree to submit itfor publication.

Corresponding author

Correspondence to Hui Zeng.

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Competing interests

RPG is a consultant to NexImmune Inc. Nanexa Pharma Ascentage Pharm Group and Antengene Biotech LLC, Medical Director of FFF Enterprises Inc.; Partner in AZCA Inc.; Board of Directors of Russian Foundation for Cancer Research Support and Scientific Advisory Board: StemRad Ltd.

Ethics approval and consent to participate

The study was conducted in accordance with the Declaration of Helsinki, the International Conference on Harmonization Good Clinical Practice guideline and received approval from the Ethics Committee of the First Affiliated Hospital of Jinan University (KY-2023-117) and is registered on clinicaltrials.gov (NCT05919199). Informed consent was obtained from all participants. All clinical data including PET/CT images and bone marrow samples were obtained and published after written informed consent. The experiments of PDX models were approved by the Institutional Animal Care and Use Committee of Jinan University (JNU-IACUC) and conformed to all relevant regulatory standards. Mice were kept in ventilated cages under pathogen-free conditions with 12 h light and dark cycle and given water and food ad libitum. All 18F-FDG experiments were conducted with the approvals mentioned above and with proper radiation protection.

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Glucose uptake capacity of leukaemia cells in vitro correlates with response to induction therapy in acute myeloid leukaemia (1)

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Deng, S., Du, J., Huang, K. et al. Glucose uptake capacity of leukaemia cells in vitro correlates with response to induction therapy in acute myeloid leukaemia. Leukemia (2024). https://doi.org/10.1038/s41375-024-02469-3

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  • DOI: https://doi.org/10.1038/s41375-024-02469-3

Glucose uptake capacity of leukaemia cells in vitro correlates with response to induction therapy in acute myeloid leukaemia (2024)
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